Kallikrein Proteins are Mysteriously Expressed in Several forms of Cancer : A Part from The Book Chapter : An In-silico Study of Pathological Angiogenesis; Design of Anticancer Agent Inhibiting KLK – 12

Kallikrein proteins are mysteriously expressed in several forms of cancer. Additionlly, Kallikrein-related peptidase 6 (KLK6) overexpression is commonly observed in primary tumors of colorectal cancer (CRC) patients and has been associated with tumor aggressiveness, metastasis, and poor prognosis. Kallikrein gene (KLK) promote angiogenesis directly by disrupting the Extra Cellular Matrix (ECM) barriers or indirectly by activating multiple Matrix Metalloproteinases (MMPs) through the Urokinase Plasminogen Activator/UPA Receptor (uPA/UPAR) activation pathway. Human tissue kallikreins (KLKs) are pre-proenzymes containing an amino-terminal signal sequence (Pre), a propeptide (Pro) that preserves them as inactive precursors (zymogens), and the serine-protease domain responsible for catalytic activity. KLK-12 is a recently discovered kallikrein expressed in breast cancer tissues.

Author(s) Details:

Jyothi Bandi,
Department of Chemistry, University College of Science, Osmania University, Hyderabad – 500007, Telangana State, India.

Navaneetha Nambigari,
Department of Chemistry, University College of Science, Osmania University, Hyderabad – 500007, Telangana State, India and Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad – 500004, Telangana State, India.

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