Oncogenic Processes of ATL are Complicated: A Part from The Book Chapter: Multistep Oncogenesis of Adult T-cell Leukemia/ Lymphoma and Significance of Carbon Anhydrase IX Activated via NF-k B and PI3K

Oncogenic processes of ATL are complicated. Its two step model was first proposed, and this was soon improved by the three step model. According to the two step model, Tax activates expression of various genes and factors related to cell proliferation at the early stage, while in the next stage, HBZ moderates and suppresses the activities of Tax and plays the important role in ATL oncogenesis. In contrast, by the three step model, these two steps are redefined as the early and intermediate steps and the third final stage is added. In this three step model, additional events in host cells are thought to be critical to finalization of oncogenic processes in ATL. In both models, the key players of the first and second stages are Tax and HBZ, respectively.

Author(s) Details:

Mitsuru Sakitani,
Institute CCC, Kobe, Hyogo, 651-2242, Japan.

To Read the Complete Chapter See Here

Related Posts

Natural antioxidants

D. oliveri have been Studied to Possess Flavonoids: A Part from The Book Chapter : Antiplasmodial Potentials and GC-MS Analysis of Bioactive Compounds in Methanol and Ethanol Leaf Extracts of Daniellia oliveri

Malaria inflammatory and oxidative pathophysiology have been reported to be associated with the production of hydroxyl free radical by the hepatocytes, D. oliveri have been studied to…

DNA markers

Combining DNA Microarray Technology and Polymorphism Study: A Part from The Book Chapter : Identification of Novel Genetic Markers Based on DNA Polymorphisms and Their Application in Animal Production

DNA microarray chip technology is a useful tool for investigating differentially-expressed genes in animals. Combining DNA microarray technology and polymorphism study, studies in our laboratory identified novel…

Sweet potato

SPCSV is Transmitted by the Whitefly Especially Bemisia Tabaci: A Part from The Book Chapter: Management of Sweet Potato Virus Disease Using Prophylactic Measure Strategy

SPCSV is transmitted by the whitefly especially Bemisia tabaci, as they fly from plant to plant by feeding up the plant sap to cause many plants become…

Arsenic contamination

Rice Cultivation Becomes Contaminated With Arsenic Through the Application of Fertilizers: A Part from The Book Chapter : Current Status of Arsenic Contamination and the Characterization of Dissimilatory Arsenate-Reducing Bacteria

Arsenic is considered the primary contaminant of concern in soil ecosystems regarding pollution control and soil ecological risk assessment. Many authors have reported extensive arsenic contamination in…

Mosquito control

The Transmission of Vector-Borne Diseases Like Malaria: A Part from The Book Chapter: Midgut Binding Activity of Mosquitocidal Extracellular Protein of Pseudomonas fluorescens Strain

Controlling mosquitoes is essential to prevent the transmission of vector-borne diseases like malaria, dengue, chikungunya, Japanese encephalitis, and filariasis. The intensive use of chemical insecticides led to…

DNA

DNA is Degraded by Enzymes Like Deoxyribonuclease: A Part from The Book Chapter : Homemade Molecular Devices, Detections and Methods

DNA is degraded by enzymes like deoxyribonuclease (DNase), Restriction endonucleases, S-1 nuclease, exonucleases like Exo-1, Polymerase- δ, ε, γ, p53 and microbial contaminations. These enzymes are present…

Leave a Reply