Epigenetic Mechanisms are Increasingly Considered Major Factors Contributing to MB Pathogenesis : A Part from The Book Chapter : Unveiling the Potential of Combined BET and HDAC Inhibition in MYC-driven Medulloblastoma Treatment: A Promising Epigenetic Approach

Epigenetic mechanisms are increasingly considered major factors contributing to MB pathogenesis. Particularly, dysregulation of epigenetic/chromatin mod- ifiers, including histone acetylation/methylation marks, is very common in in Group 3 and Group 4 MBs, com- pared with other subgroups. Histone acetylation marks play important roles in regulating gene transcription, including transcription of MYC oncogene. These marks are written by histone acetyltransferases (HATs), erased by histone deacetylases (HDACs) and read by bromodomain extra-terminal (BET) proteins. Importantly, HDACs and BET proteins have been shown to regulate MYC transcription and its associated tumori-genic programs, making them rational targets for MYC-driven MB therapy.

Author(s) Details:

Matthew J. Kling,
Department of Oral Biology, Creighton University, School of Dentistry, Omaha, NE 68102, USA and Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Varun Kesherwani,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Nitish K. Mishra,
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Gracey Alexander,
Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Erin M. McIntyre,
Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Sutapa Ray,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Kishore B. Challagundla,
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Shantaram S. Joshi,
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Don W. Coulter,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Nagendra K. Chaturvedi,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology and Oncology Division, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198, USA.

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